RNA Details
Disease Name
pancreatitis chronic
Tissue
pancreas
RNA Symbol
Col4a1
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
RT-PCR; cell prolimmunofluorescenceeration assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism
Year
2004
Function
"The effect of troglitazone on alpha1(i) procollagen mrna and mcp-1 mrna was unaffected by inhibition of endogenous ppargamma1 receptor activity. These results suggest that troglitazone may serve as novel therapeutic agent for the treatment of chronic pancreatitis. The antifibrotic effect of troglitazone appears to be mediated, in part, via a ppargamma-independent mechanism."